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3,5-Dimethylpiperidine : an insider’s guide to specs, sourcing, and real-world use I’ve watched secondary amines swing from quiet commodity to “can you ship next week?” status, and—honestly— 3,5-Dimethylpiperidine is in that sweet spot now. Demand from pharma and crop-protection intermediates is up, while buyers want tighter GC specs and faster documentation. The supply chain out of North China, including Shijiazhuang, seems steady, which is refreshing. Below I’ll break down what matters: technical specs, testing norms, application scenarios, customization levers, and a straight-talking vendor comparison. If you’re benchmarking suppliers, this will save time. Quick product snapshot Name 3,5-Dimethylpiperidine Secondary cyclic amine Molecular formula C7H15N MW 113.20 CAS 35794-11-7 Regulatory tracking UN No. 1993 Flammable liquid, n.o.s. (transport) Appearance Colorless–pale yellow liquid Visual Assay (GC) ≥ 98.0% (typical) GC-FID, ICH Q2-aligned validation Water (KF) ≤ 0.5% (typical) Karl Fischer, ISO 760 Density (20 °C) ≈ 0.84–0.88 g/cm³ ASTM D4052 or equivalent Flash point ≈ 25–35 °C (PMCC) ASTM D93; real-world may vary Shelf life 24 months, sealed Cool, dry, inhibitor-free storage Applications and industry trends Use-cases I keep seeing: pharma intermediates (sterically tuned bases), crop-protection synthons, epoxy-curing blends, and ligand/auxiliary development where the 3,5-dimethyl pattern helps with selectivity. Many customers say 3,5-Dimethylpiperidine gives cleaner reductive amination profiles versus less hindered amines. Market-wise, buyers want low-residual solvents and documented cis/trans ratio control—custom cuts are a quiet differentiator. Process notes (how it’s typically made) Feedstocks: 3,5-dimethylpyridine (lutidine) or equivalent precursors. Method: catalytic hydrogenation/reductive routes, followed by neutralization and fractional distillation. QC: GC purity and residual solvents; KF for water; density/RI check; ID via NMR (upon request). Packaging: 20 kg jerrycans or 160–180 kg steel drums; nitrogen blanket recommended. Safety/Logistics: ship under UN 1993; GHS SDS; IMDG/IATA compliant labeling. Vendor comparison (indicative) Criteria Sincere Chemicals Trader A Broker B Origin Jinling Mansions No.106-1 East Yuhua Rd., Shijiazhuang, Hebei, China Mixed Mixed Purity (GC) ≥ 98% typical 96–98% Varies Lead time 7–14 days ex-works 3–6 weeks Uncertain Docs COA, SDS (GHS), TDS, REACH status COA + SDS Limited Customization Cis/trans ratio talk, solvent profile, packs Basic Minimal Testing standards and data habits What good labs do: GC-FID for assay (validated to ICH Q2(R2)), KF water per ISO 760, density (ASTM D4052), RI (ASTM D1218), flash point (ASTM D93). Typical COA numbers we’ve seen: assay 98.5–99.5%, water 0.05–0.3%. Always confirm on the shipment COA. Case notes from the field Agrochem lab, EU: switching to 3,5-Dimethylpiperidine trimmed a side-reaction in a reductive amination; they reported ~3% better GC area for the target and easier workup. “Not dramatic, but it stuck,” they told me. Medchem startup, US: with a cis/trans-selective cut of 3,5-Dimethylpiperidine , crystallization behaved; yield held steady, impurity ≤ 0.15% each by GC. They liked the responsiveness on small-pack (5 × 20 kg) deliveries. Customization checklist Cis/trans ratio discussion (where relevant to stereochemical outcomes). Residual solvent targets; low-water cuts for moisture-sensitive couplings. Packaging: 20 kg HDPE, 160–180 kg drum; inert gas blanket; tamper-evident seals. Docs: full COA, SDS (GHS), stability statement, method summaries on request. Bottom line: if you need consistent 3,5-Dimethylpiperidine with real QC support and reasonable lead times, shortlist producers who publish method alignment (ICH/ISO/ASTM) and commit to re-test dates—not just “expiry.” Authoritative citations PubChem compound query for 3,5-Dimethylpiperidine: https://pubchem.ncbi.nlm.nih.gov/#query=3,5-Dimethylpiperidine ICH Q2(R2) – Validation of Analytical Procedures: https://www.ema.europa.eu/en/ich-q2r2-validation-analytical-procedures UNECE UN 1993 transport guidance (Dangerous Goods): https://unece.org/transport/dangerous-goods ISO 760 – Determination of water (Karl Fischer): https://www.iso.org/standard/74341.html